Bakersfield.com

Dear Editor,

With the upcoming month of November being Diabetes Awareness month and World Diabetes Day falling on November 14th, the following story may be of interest to your newspaper.

There are several doctors in California that are participating in an international clinical research trial sponsored by Tolerx, Inc and funded by the Juvenile Diabetes Research Foundation. Some of the doctors and diabetic educators in your region have been informed of this trial.

Tolerx’s Phase 3 candidate, otelixizumab (an anti-CD3 antibody targeting autoimmune type 1 diabetes). This could be the first disease-modifying agent for Type 1 Diabetes since insulin was discovered in 1921.  We are in the process of bringing forth an innovative short-term treatment option that could halt the autoimmune attack that causes Type 1 Diabetes, thus impacting the long-term complications from the disease.  The economic burden of diabetes complications was estimated to be $174 billion in 2007.  The Diabetes Control and Complications study has demonstrated that preservation of endogenous insulin or c-peptide secretion can substantially reduce the long-term complications of Type 1 Diabetes, therefore having a significant economic effect.  Data presented at ADA on otelixizumab demonstrated that 4 years after a single course of therapy, patients were making significantly more endogenous insulin than control patients, creating a real potential to reduce the long-term complications from the disease and reduce this tremendous economic weight.
  
We are currently conducting DEFEND, a phase 3 study of otelixizumab.  There is great information on our website at www.defendagainstdiabetes.com or  www.tolerx.com.  For information on World Diabetes Day, please visit www.worlddiabetesday.org.

Please consider interviewing a company representative, one of the investigative doctors in your area, or a subject who is participating in this clinical research trial for different aspects and view points.

Thank you for your time and consideration.


Regards,
Samantha Nguyen
DEFEND Recruitment Specialist
30 Verona Lane
Foothill Ranch, CA 92610
ph. 857-998-9521
alt ph. 714-865-3384
snguyen@tolerx.com